1999.09 - 2002.07  College of life sciences, Shandong University

2005.09 - 2008.07  Master, Beijing University of Agriculture

2008.08 - 2011.12  Ph.D., Institute of Basic Medical Sciences, Peking Union Medical College

2012.01 - 2015.12  Assistant professor, Institute of Biophysics, Chinese Academy of Sciences

2016.01 - 2022.10  Associate professor, Institute of Biophysics, Chinese Academy of Sciences

Cancer stem cells (CSCs) possess the ability to self-renew and differentiate. CSCs may contribute to tumor initiation, metastasis, recurrence as well as drug resistance. Our current research interests include studying the molecular mechanisms of liver CSCs self-renewal, discover novel markers of liver CSCs, and provide novel drug targets for personal therapy of liver cancer.

1. Wang Y^#*, Wang J^#, Li X^#, Xiong X^#, Wang J, Zhou Z, Zhu X, Yang G, Dominissini D, He L, Tian Y*, Yi C*, and Fan Z*. N1-methyladenosinemethylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021 Nov 2;12(1):6314.

2. Gu Y^#, Wang Y^#*, He L^#, Zhang J^#, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y*, and Fan Z*. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Mol Cancer. 2021, 20(1):132.

3. Wang Y^#, He L^#, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, and Fan Z. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015（16）；413-425. (^#equal contribution)

4. Wang Y^#, Zhu P^#, Wang J^#, Zhu X^#, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y, and Fan Z. Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling. J Hepatol. 2018;69:861-872. (^#equal contribution)

5. Wang Y^#, Zhu P^#, Luo J^#, Wang J^#, Liu Z^#, Wu W, Du Y, Ye B, Wang D, He L, Chen R, Tian Y, and Fan Z. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO J. 2019 38(17):e101110. (^#equal contribution)

6. Wang Y^#, Song G^#, Qiu L, Qin X, Liu H, Li F, Wang X, Guo S, Zhang Y, and Li Z. Elevated Serum Levels of Circulating Immunoinflammation-Related Protein Complexes Are Associated with Cancer. J Proteome Res. 2014, 13(2): 710-719. (^#equal contribution)

7. Wang Y, Zhang Z, Shen H, Lu Y, Li H, Ren X, Wu G. TGF-β1/Smad7 signal pathway stimulates renal tubuloinsterstitial fibrosis induced by AAⅠ. J Recept Sig Transd Res. 2008, 28: 4, 413-428.

8. Zhu P^#, Wu J^#, Wang Y^#, Zhu X^#, Lu T^#, Liu B, He L, Ye B, Liu B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Y Du, li C, He L, Ren W, Wu X, Tian Y, and Fan Z. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. Nat Cell Biol. 2018; 20: 1134-1144. (^#equal contribution)

9. Wu J^#, Zhu P^#, Lu T^#, Du Y^#, Wang Y^#, He L, Ye B, Liu B, Yang L, Wang J, Gu Y, Lan J, Hao Y, He L, and Fan Z. The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling. J Hepatol. 2019;70(5):918-929. (^#equal contribution)

10. Zhu P^#, Wang Y^#, Huang G, Ye B, Liu B, Wu J, Y Du, He L, and Fan Z. lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 2016; 23 (7):631-639. (^#equal contribution)

11. Zhu P^#, Wang Y^#, Wu J, Huang G, Liu B, Ye B, Y Du, G Gao, Y Tian, He L, and Fan Z. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608. (^#equal contribution)

12. Zhu P^#, Wang Y^#, He L^#, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, and Fan Z. Zic2 Drives Self-renewal of Human Liver Cancer Stem Cells. J Clin Invest. 2015;125(10):3795-3808. (^#equal contribution)

13. Zhu P^#; Zhu X^#; Wu J^#; He L^#; Lu T^#; Wang Y; Liu B; Ye B; Sun L; Fan D; Wang J; Yang L; Qin X; Du Y; Li C; He L; Ren W; Wu X; Tian Y; Fan Z. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019, 20(2):183-+ DOI:10.1038/s41590-018-0297-6.

14. Zhu P, Wang Y, Du Y, He L, Huang G, Zhang G, Yan X, and Fan Z. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signaling. Nat Commun. 2015;6:7122.

15. Ye B^#; Liu B^#; Yang L^#; Zhu X^#; Zhang D^#; Wu W; Zhu P; Wang Y; Wang S; Xia P; Du, Y; Meng S; Huang G; Wu J; Chen R; Tian Y; Fan Z. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3. EMBO J. 2018, 37(8).

16. Ye B^#; Liu B^#; Hao L^#; Zhu X^#; Yang L^#; Wang S; Xia P; Du Y; Meng S; Huang G; Qin X; Wang Y; Yan X; Li C; Hao J; Zhu P; He L; Tian Y; Fan Z. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018, 9(1).

17. Li C^#; Du Y^#; Yang Z^#; He L; Wang Y; Hao L; Ding M; Yan R; Wang J; Fan Z*. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016, 76(5):1273-1283.

18. Ye B^#, Li C^#, Yang Z^#, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y, and Fan Z. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014, 211: 2439-2454.

19. Yang X^#, Xu M^#, Wang Y, Xia P, Wang S, Ye B, Tong L, Jiang T, and Fan Z. Molecular mechanism for self-protection against type VI secretion system in Vibrio cholerae. Acta Crystallogr D Biol Crystallogr. 2014, 70(4): 1094-1103.

20. Song G, Liu Y, Wang Y, Ren G, Guo S, Ren J, Zhang L, and Li Z. Personalized biomarkers to monitor disease progression in advanced non-small-cell lung cancer patients treated with icotinib. Clinica Chimica Acta. 2015, 440:44-48.

21. Chen G, Wang Y, Qin X, Li H, Guo Y, Wang Y, Liu H, Wang X, Song G, Li F, Guo S, Qiu L, and Li Z. Change in IgG1 Fc N-linked glycosylation in human lung cancer: age- and sex-related diagnostic potential. Electrophoresis. 2013, 34: 2407-2416.

22. Chen G, Zhang L, Wang Y, Guo Y, Liu H, and Li Z. Letter to the editor. Probing gender-specific change in IgG1 Fc-galactosylation in non-small cell lung cancer patients treated with epidermal growth factor receptor inhibitor. Rapid Commun Mass Spectrom. 2013, 27, 1168-1172.

23. Chen G, Wang Y, Qiu L, Qin X, Liu H, Wang X, Wang Y, Song G, Li F, Guo Y, Li F, Guo S, and Li Z. Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer. J Proteomic. 2012, 75(10), 2824-2834.

24. Guo Y, Wang X, Qiu L, Qin X, Liu H, Wang Y, Li F, Chen G, Song G, Guo S, and Li Z. Probing gender-specific lipid metabolites and diagnostic biomarkers for lung cancer using Fourier transform ion cyclotron resonance mass spectrometry. Clin Chim Acta. 2012, 414, 135-141.

25. Li J, Zhang Z, Wang D, Wang Y, Li Y, and Wu G. TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Sig Transd Res. 2009, 29(5): 280-285.

(From Yanying Wang, May 31, 2022)