2002.09 - 2006.06  B.S., Wuhan University

2006.09 - 2011.06  Ph.D., Wuhan University

2012.03 - 2014.04  Postdoctoral associate, Institute of Biophysics, CAS

2014.04 -                Associate professor, Institute of Biophysics, CAS

2015  The Second-Class Prize for State Natural Science Award of China (the fourth author)

2013  National Excellent Doctoral Dissertation of China

2011 and 2006 Outstanding Graduate Award, Wuhan University

1. The regulation of T cells differentiation

2. The regulation of dendritic cells differentiation

3. Anti-tumor immunity and immunotherapy

1. Li Y, Cong Y, Jia M, He Q, Zhong H, Zhao Y, Li H, Yan M, You J, Liu J, Chen L, Hang H, Wang S. Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy. Nat Commun. 2021 Feb 11;12(1):951.

2. Lu N, Li Y, Zhang Z, Xing J, Sun Y, Yao S, Chen L. Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4. Nat Commun. 2018 Feb 21; 9(1):742.

3. Xu M, Liu M, Du X, Li S, Li H, Li X, Li Y, Wang Y, Qin Z, Fu YX, Wang S. Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype. J Immunol. 2015 May 15;194(10):4997-5006.

4. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y, Shu HB. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. J Biol Chem. 2013 Jun 14;288(24):17908-17.

5. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y, Shu HB. RAVER1 is a coactivator of MDA5-mediated cellular antiviral response. J Mol Cell Biol. 2013 Apr; 5(2):111-9.

6. Li Y, Chen R, Zhou Q, Li C, Xu Z, Wang S, Mao AP, Zhang X, He W and Shu HB. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11770-5.

7. Wang X, Li Y, Mao A, Li C, Li Y, Tien P. Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex. Cell Mol Immunol. 2010 Sep; 7(5), 341-8.

8. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P and Shu HB. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. Proc Natl Acad Sci U S A. 2010 Jan 12; 107, 815-820.

9. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang FQ and Shu HB. ISG56 is a negative regulator of virus-triggered signaling and cellular antiviral response. Proc Natl Acad Sci U S A. 2009 Mar 20; 106, 7945-50.

10. Zhong B, Zhang L, Lei CQ, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity. 2009 Mar 20; 30, 397-407.

11. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB. The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity. 2008 Oct 17; 29, 538–550.

(From Ying Li, November 9, 2021)