1998.09 - 2002.07  Yantai University, Bachelor

2005.01 - 2005.07  UCSC, Visiting Scholar

2002.09 - 2008.07  Peking University, Ph.D

2008.07 - 2010.06  China Academy of Chinese Medical Sciences, Postdoc

2010.07 - 2013.12  Institute of Biophysics, CAS, Research assistant

2014.01 - 2022.09  Institute of Biophysics, CAS Research associate

Dendrites are the branched projections of a neuron which receive signals from other neural cells. They play a critical role in integrating synaptic inputs to the cell body. The malfunction of dendrites has been shown to be associated with many human diseases, such as autism, Down, Rett, Fragile-X syndrome et al.I am interested in the molecular mechanism of dendrite morphogenesis and maintenance. Here I will use the PVD neuron of C. elegans as the model system to isolate new genes controlling PVD neuron development and maintenance.

1. Huichao Deng^#, Xinhua Qiao^#, Ting Xie, Wenfeng Fu, Hang Li, Yanmei Zhao, Miaomiao Guo, Yaqian Feng, Ligong Chen, Yan Zhao, Long Miao, Chang Chen*, Kang Shen*, and Xiangming Wang*. SLC-30A9 is required for Zn²⁺ homeostasis, Zn²⁺ mobilization, and mitochondrial health. Proc Natl Acad Sci USA, 2021, Aug 31;118(35):e2023909118.

2. Yinsuo Zhao, Eli Song, Wenjuan Wang, Chung-Han Hsieh, Xinnan Wang, Wei Feng*, Xiangming Wang*, and Kang Shen*. Metaxins are core components of mitochondrial transport adaptor complexes, Nat. Commun., 2021 Jan 4;12(1):83.

3. Qing Qin, Ting Zhao, Wei Zou, Kang Shen*, and Xiangming Wang*. An Endoplasmic Reticulum ATPase Safeguards Endoplasmic Reticulum Identity by Removing Ectopically Localized Mitochondrial Proteins, Cell Rep., 2020 Nov 10;33(6):108363.

4. Bin Zhang^#, Lilin Zhao^#, Jing Ning, Jacob D Wickham, Haokai Tian, Xiaoming Zhang, Meiling Yang, Xiangming Wang, Jianghua Sun. miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascaroside signaling. BMC Biol, 2020, Nov 27;18(1):184.

5. Xianzhuang Liu, Xiangyang Guo, Liling Niu, Xixia Li, Fei Sun, Junjie Hu, Xiangming Wang*, and Kang Shen*. Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites, Nat. Commun., 2019, Feb 4;10(1):568.

6. Rui Dong, Ting Zhu, Lorena Benedetti, Swetha Gowrishankar, Huichao Deng, Yiying Cai, Xiangming Wang, Kang Shen*. Pietro De Camilli*,The inositol 5-phosphatase INPP5K participates in the fine control of ER organization, J Cell Biol, 2018, Oct 1;217(10):3577-3592.

7. Shuai Zhang, Zhibin Fan, Ping Qiao, Yinsuo Zhao, Yanan Wang, Da Jiang, Xiangming Wang, Xiaojuan Zhu, Yu Zhang, Baiqu Huang, Jun Lu*, Xiaoxue Li*. miR-51 regulates GABAergic synapses by targeting Rab GEF GLO-4 and lysosomal trafficking-related GLO/AP-3 pathway in Caenorhabditis elegans, Dev Biol, 2018, Apr 1;436(1):66-74.

8. Ting Zhu^#, Xing Liang^#, Xiangming Wang*, Kang Shen*. Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells, J Cell Sci., 2017, 130(23):4063-4071.

9. Xianzhuang Liu, Xiangming Wang*, and Kang Shen*. Receptor tyrosine phosphatase CLR-1 acts in skin cells to promote sensory dendrite outgrowth, Dev Biol, 2016, May 1;413(1):60-9.

10. Xiangming Wang*, Jianhong Liu, Zhiwen Zhu, Guangshuo Ou. The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration, Dev Biol., 2015, 399(2): 306-14.

11. Xing Liang, Xintong Dong, Moerman, D. G., Kang Shen*, and Xiangming Wang*. Sarcomeres Pattern Proprioceptive Sensory Dendritic Endings through UNC-52/Perlecan in C. elegans, Dev. cell, 2015, 33(4): 388-400.

Preview in the same isuue: Jiang N, Parrish JZ.Muscles get dendrites into shape. Developmental cell, 2015, 33, 369-370.

Recommended by F1000 https://facultyopinions.com/prime/725503624#eval793507646

12. Xiangming Wang, Fanli Zhou, Sijing Lv, Peishan Yi, Zhiwen Zhu, Yihong Yang, Guoxin Feng, Wei Li, and Guangshuo Ou*. Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration, Proc Natl Acad Sci U S A., 2013, 110(27): 11175-11180.　　

13. Ze Cheng^#, Peishan Yi^#, Xiangming Wang, Yongping Chai, Guoxin Feng, Yihong Yang, Xing Liang, Zhiwen Zhu, Wei Li*& Guangshuo Ou*. Conditional targeted genome editing using somatically expressed TALENs in C. elegans, Nature Biotechnology, 2013, volume 31, pages 934–937.　　

14. Guoxin Feng^#, Peishan Yi^#, Yihong Yang^#, Yongping Chai^#, Dong Tian, Zhiwen Zhu, Jianhong Liu, Fanli Zhou, Ze Cheng, Xiangming Wang, Wei Li, Guangshuo Ou*. Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression, Development, 2013, 140: 3838-3847.　　

15. Yongping Chai^#, Wei Li^#, Guoxin Feng, Yihong Yang, Xiangming Wang & Guangshuo Ou*. Live imaging of cellular dynamics during Caenorhabditis elegans postembryonic development, Nat Protoc, 2012, Dec;7(12):2090-102.　　

16. Xiangming Wang*, Xiaoyan Wang, Lianda Li, Danqiao Wang*. Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16, Biochem Biophys Res Commun, 2010, Oct 1;400(4):613-8.　　

17. Xiangming Wang^#, Min Liu^#, Weida Li, Christopher D. Suh, Zuoyan Zhu, Yishi Jin, Qichang Fan*. The function of a spindle checkpoint gene bub-1 in C. elegans development, PLoS One, 2009, Jun 15;4(6):e5912.　

18. Xiangming Wang, Christopher D. Suh, Zuoyan Zhu, Qichang Fan*. Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development, Biochem Biophys Res Commun, 2007, Aug 10;359(4):965-71.