Biographical Sketch

Dr. Minmin Liang is Professor of Nanobiology and Nanomedicine at Institute of Biophysics, Chinese Academy of Sciences (CAS). Dr.Liangobtained her Ph.D from Research Center for Eco-Environmental Sciences, CAS on bioelectrochemistry and biosensors under the supervision of professor Liang-hong Guo in 2008. She then moved to USA and carried out post-doctoral research work with Professor Donald J. Hnatowich at the University of Massachusetts Medical School in the field of Radiology. Dr.Liang extended her research into molecular cancer imaging and joined theInstitute of Biophysics, CAS. Since 2010, she focuses on the development of novel contrast agents for tissue- and organ-specific targeting and diagnosis. Of particular interest is targeted nanomaterials, which can be used for early diagnosis of disease and monitoring therapy response by specifically visualizing target tissue with high signal accumulation and by avoiding nonspecific uptake in normal background tissues.

Education and Training

1997.09 - 2001.07  B.Sc.,Chemistry, Shandong Institute of light Industry,China

2002.09 - 2005.03  Master, Beijing Institute of Technology, China

2005.03 - 2008.02  Ph.D., Research Center for Eco-Environmental Sciences, CAS

2008.03 - 2010.03  Postdoctoral researcher, UMass Medical School, USA

2010.06 - 2014.12  Associate professor, Institute of Biophysics, CAS

2014.12 - 2019       Professor, Institute of Biophysics, CAS

1. Liang M, Cheng D, Choi HS, Yan X*., et al. Bioengineered H-Ferritin nanocages for quantitative imaging of vulnerable plaques in atherosclerosis, ACS nano, 2018, DOI: 10.1021/acsnano.8b04158

2. Jiang B, Duan D, Liang M*, Yan X*, Standardization of nanozyme catalytic activity and kinetics, Nature Protocols, 2018, 13: 1506-1520. (^#Co-first authors)

3. Zhao Y^#, Liang M^#, Li X, et al. Bioengineered magnetoferritinnanoprobes for single-dose nuclear-magnetic resonance tumor imaging. ACS nano, 2016, 10(4): 4184-4191. (^#Co-first authors)

4. Liang M, Fan K, Zhou M, Duan D, Zheng J, Yang D, Feng J, Yan X.，H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection, Proc Natl AcadSci U S A. 2014, 14;111(41):14900-5.

5. Liang M, Fan K, Pan Y, Jiang H, Wang F, Yang D, Lu D, Feng J, Zhao J, Yang L, Yan X., Fe3O4 Magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent. Anal Chem. 2013, 2;85(1):308-12.

6. Fan K, Cao C, Pan Y, Lu D, Yang D, Feng J, Song L, Liang M*, Yan X*. Magnetoferritin nanoparticles for targeting and visualizing tumour tissues. Nat Nanotechnol. 2012, 17;7(7):459-64.

7. Zhuang J, Fan K, Gao L, Lu D, Feng J, Yang D, Gu N, Zhang Y, Liang M*, Yan X*，.Ex Vivo Detection of Iron Oxide Magnetic Nanoparticles in Mice Using Their Intrinsic Peroxidase-Mimicking Activity. Mol Pharm. 2012, 9 (7), 1983-1989.

8. Liang M, Liu X, Liu G, Dou S, Cheng D, Liu Y, Rusckowski M, Hnatowich DJ. Reducing the background fluorescence in mice receiving fluorophore/inhibitor DNA duplexes. Mol. Pharm. 2011, 8(1):126-32.

9. Liang M, Liu X, Cheng D, Liu G, Dou S, Wang Y, Rusckowski M, Hnatowich DJ. Multimodality nuclear and fluorescence tumor imaging in mice using a streptavidin nanoparticle. Bioconjug. Chem. 2010, 21(7):1385-8.

10. Liang M, Liu X, Cheng D, Nakamura K, Wang Y, Dou S, Liu G, Rusckowski M, Hnatowich DJ.Optical antisense tumor targeting in vivo with an improved fluorescent DNA duplex probe.Bioconjug. Chem. 2009, 20(6):1223-7.

11. Liang M, Liu X, Nakamura K, Chen X, Cheng D, Liu G, Dou S, Wang Y, Rusckowski M, Hnatowich DJ. A convenient thiazole orange fluorescence assay for the evaluation of DNA duplex hybridization stability. Mol. Imaging Biol. 2009, 11(6):439-45.

12. Liang M, Liu S, Wei M, Guo LH, Photoelectrochemical oxidation of DNA by ruthenium tris(bipyridine) on a tin oxide nanoparticle electrode, Anal. Chem., 2006, 78 (2): 621-623.

13. Liang M, Guo LH. Application of nanomaterials in environmental analysis and monitoring. J. Nanosci Nanotechnol. 2009, 9(4):2283-2289.

14. Liang M, Guo LH, Photoelectrochemical DNA sensor for the rapid detection of DNA damage induced by styrene oxide and the Fenton reaction, Environ. Sci. Technol., 2007, 41(2): 658-664.

15. Liang M, Jia S, Zhu S, Guo LH, Photoelectrochemical sensor for the rapid detection of in-situ DNA damage induced by enzyme-catalyzed Fenton reaction, Environ. Sci. Technol., 2008, 42 (2): 635-639.

16. Liang M, QI M, Zhang C, Zhou S, Fu R, Huang J, Gas chromatography-mass spectrometry analysis of volatile compounds from HouttuyniacordataThunb after extraction by solid-phase microextraction, flash evaporation and steam distillation, Anal. Chim. Acta, 2005, 531 (1): 97-104.

17. Liang M, QI M, Zhang C, Fu R, Peralkylated-beta-cyclodextrin used as gas chromatographic stationary phase prepared by sol-gel technology for capillary column, J. Chromatogr. A, 2004, 1059 (1-2): 111-119.

(From Minmin Liang, September 12, 2018)