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Na Yang (Guest), Ph.D, Prof.

Winner of the Excellent Young Scientists 
Excellent Member of the Youth Innovation Promotion Association of CAS


Research Interests: Structural mechanisms of epigenetics


Email: yangna@ibp.ac.cn


Tel: 010-64889371


Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China


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Biography

1996.09 - 2000.07  B.Sc., Biophysics, Peking University, Beijing, China

2000.09 - 2005.07  Ph.D., Structural biology, Institute of Biophysics, CAS

2005.07 - 2006.03  Research assistant, Institute of Biophysics, CAS

2006.04 - 2008.10  Postdoctoral associate, Peking University

2008.10 - 2013.12  Associate professor, Institute of Biophysics, CAS

2013.12 - 2019    Professor, Institute of Biophysics, CAS

2015.10 - 2019      Professor, University of the Chinese Academy of Sciences (UCAS)

Awards

2016  Excellent Young Scientists Fund

2015  Excellent Member of the Youth Innovation Promotion Association of CAS

2012  Second prize of Young Scientist Forum, the Chinese Society of Biochemistry and Molecular Biology

2011  Lu Jiaxi Young Talent Award of Chinese Academy of Sciences

2006  First prize of Chinese Postdoctor Award

2005  President prize of Chinese Academy of Sciences

2004  First prize of Director Scholarship of Institute of Biophysics

2001  Excellent Graduate Student in the graduate school of CAS

Membership in Academies & Societies

2008 - 2009  Secretary, Chinese Crystallographic Society

2009 -           Secretary General, Molecular Biophysics Section of the Chinese Biophysical Society

2014 -           Consultant, Commission on Biological Macromolecules, IUCr

2015 -           Member, Youth Federation of the Chinese Academy of Sciences

Research Interests

Dr. Na Yang has been carrying out structural mechanism studies of epigenetics, including histone modifications and nucleosome assembly, as well as RNA-protein interactionsduring the mRNA localization procedure. During her 16-year research in structural biology, has published 31 SCI research articles in prestigious journals such as Science, NSMB, PNAS, Genes & Dev., JBC, and written 1 book chapterof Handbook of Proteolytic Enzymes (ISBN 9780123822192, Chapter 681).

Grants
 
Selected Publications

1. Fu, W. Q., Liu, N., Qiao, Q., Wang, M., Min, J. R., Zhu, B.*, Xu, R. M.* and Yang, N.* (2016) Structural Basis for Substrate Preference of SMYD3, A SET Domain-containing Protein Lysine Methyltransferase. J. Biol. Chem., Vol. 291, 9173-9180.

2. Yang, N.*, Yu, Z. Y., Hu, M. L.,Wang, M., Lehmann, R.* and Xu, R. M.* (2015) Structure of Drosophila Oskar reveals a novel RNA binding protein. Proc. Natl. Acad. Sci .USA, Vol. 112, 11541-11546.

3. Cao, D.F., Wang, M., Qiu X.Y., Liu D.X., Jiang H.L., Yang N.* and Xu R.M*. (2015) Structural basis for allosteric, substratedependentstimulation of SIRT1 activityby resveratrol. Genes & Dev. Vol. 29, 1316-1325.

4. Wang, H., Wang, M., Yang, N.* and Xu, R. M.*(2015) Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2. Protein & Cell, Vol. 6, 693-697.

5. Yang, D. X., Fang, Q. L., Wang, M., Ren, R., Wang, H., He, M., Sun, Y. W., Yang, N.* and Xu, R. M.* (2013) Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat. Struct. Mol. Biol., Vol. 20, 1116-1118.

6. Yang, N.* and Xu, R. M.* (2013) Structure and function of the BAH domain in chromatin biology. Crit. Rev. Biochem. Mol. Biol., Vol. 48, 211-221.

7. Yang, N.*, Wang, W., Wang, Y., Wang, M., Zhao, Q., Rao, Z., Zhu, B.* and Xu, R. M.* (2012) Distinct mode of methyl-H3K4 recognition by tandem tudor-like domains of Spindlin1. Proc. Natl. Acad. Sci .USA, Vol. 109, 17954-17959.

8. Yang, N., Li, D. F., Feng, L., Xiang, Y., Liu, W., Sun, H. and Wang, D. C.* (2009) Structural Basis for the Tumor Cell Apoptosis-Inducing Activity of an Antitumor Lectin from the Edible Mushroom Agrocybe aegerita. J. Mol. Biol., Vol. 387(3), 694-705.

9. Yang, N., Nan, J., N., Brostromer, E., Hatti-Kaul, R., and Su, X. D.* (2008) Crystal structure of an alkaline serine protease from Nesterenkonia sp. defines a novel family of secreted bacterial proteases. Proteins: Structure, Function and Bioinformatics, Vol. 73(4), 1072-1075.

10. Liu, W.#, Yang, N.#, Ding, J. J., Huang R. H., Hu, Z. and Wang, D. C.* (2005) Structural mechanism governing the quaternary organization of monocot mannose-binding lectin revealed by a novel monomeric structure. J. Biol. Chem., Vol. 280, 14865-14876. (#Co-first authors)

11. Yang, N., Tong X., Xiang, Y., Sun, H. and Wang, D. C.* (2005) Molecular character of an antitumour lectin from the edible mushroom Agrocybe aegerita. The Journal of Biochemistry, Vol. 138, 145-150.

12. Yang, N., Xiang, Y., Zhang, Y. and Wang, D. C.* (2005) Crystallization and preliminary crystallographic studies of the recombinant antitumour lectin from the edible mushroom Agrocybe aegerita. BBA: Proteins and Proteomics, Vol. 1751, 209-212.

13. Yang, N., Liang, Y., Xiang, Y., Sun, H. and Wang, D. C.* (2005) Crystallization and preliminary crystallographic studies of an antitumour lectin from the edible mushroom Agrocybe aegerita. Protein and Peptide Letters, Vol. 12, 705-707.  

 

(From Na Yang, January 10, 2017)

 

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