Yingfeng Li, Ph.D., Associate Professor
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Member of the Youth Innovation Promotion Association of CAS
National Laboratory of Biomacromolecules, IBP
Research Interests: Epigenetic regulation in development and disease
Email: liyingfeng@ibp.ac.cn
Tel: 010-64888213
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
2006.09 – 2010.06 B.S. in Biology, School of Life Sciences, Wuhan University
2010.09 – 2019.03 Ph.D. in Biochemistry and Molecular Biology, National Institute of Biological Sciences, Beijing & Beijing Normal University
2019.03 – 2021.11 Postdoc, Institute of Biophysics, CAS
2021.11 – 2022.01 Assistant Professor, Institute of Biophysics, CAS
2022.01 - Associate Professor, Institute of Biophysics, CAS
- Awards
- Membership in Academies & Societies
- Research Interests
We take a multidisciplinary approach to understanding epigenetic reprogramming during early embryonic development. We also interrogate the mechanisms of disease-causing mutations in chromatin regulators.
- Grants
2021 - 2023 National Natural Science Foundation of China, Youth Scientist Program（32000559）
- Selected Publications
1. Zhang J#, Zhang Y#, You Q#, Huang C, Zhang T, Wang M, Zhang T, Yang X, Xiong J, Li Y, Liu C-P, Zhang Z, Xu R-M*, Zhu B*. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science. 2022, 375(6584): 1053-1058.
2. Ming X, Zhu B*, Li Y*. Mitotic inheritance of DNA methylation: more than just copy and paste. Journal of Genetics and Genomics. 2021, 48(1): 1-13.
3. Ming X#, Zhang Z#, Zou Z, Lv C, Dong Q, He Q, Yi Y, Li Y, Wang H, Zhu B*. Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration. Cell Res. 2020, 30(11): 980-996.
4. Du W, Dong Q, Zhang Z, Liu B, Zhou T, Xu R-m, Wang H, Zhu B, Li Y*. Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1. J Biol Chem. 2019, 294(22): 8907-8917.
5. Li Y#, Zhang Z#, Chen J#, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu G-L, Wang Z, Wang H, Gao S, Zhu B*. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. Nature. 2018, 564(7734): 136-140.
6. Li X, Shang E, Dong Q, Li Y, Zhang J, Xu S, Zhao Z, Shao W, Lv C, Zheng Y, Wang H, Lei X, Zhu B*, Zhang Z*. Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. J Biol Chem. 2018, 293(19): 7423-7436.
7. Huang C#, Zhang Z#, Xu M, Li Y, Li Z, Ma Y, Cai T, Zhu B*. H3.3-H4 Tetramer Splitting Events Feature Cell-Type Specific Enhancers. PLoS Genet. 2013, 9(6): e1003558.
8. Wu H, Chen X, Xiong J, Li Y, Li H, Ding X, Liu S, Chen S, Gao S, Zhu B*. Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Res. 2011, 21(2): 365-367.
(From Yingfeng Li, March 22, 2022)