2004.09 - 2008.06  Bachelor in Biological Sciences, China Agricultural University

2008.09 - 2014.01  Ph.D. in Institute of Botany, CAS

2014.01 - 2021.12  Assistant Professor, Institute of Biophysics, CAS

2022.01 -                Associate Professor, Institute of Biophysics, CAS

1. Structural and functional studies of glutamate receptor.

2. Structural and functional studies of Voltage-gated calcium channel.

3. smFRET.

^#(co) first author，*(co) corresponding author

1. Zhang, H.^#, Su, J.^#, Li, B.^#, Gao, Y., Liu, M., He, L., Xu, H., Dong, Y., Zhang, X. C., & Zhao, Y.* (2022). Structure of human glycosylphosphatidylinositol transamidase. Nature structural & molecular biology, 29(3), 203-209. https://doi.org/10.1038/s41594-022-00726-6.

2. He, L.^#, Sun, J.^#, Gao, Y.^#, Li, B., Wang, Y., Dong, Y., An, W., Li, H., Yang, B., Ge, Y., Zhang, X. C.*, Shi, Y. S.*, & Zhao, Y.* (2021). Kainate receptor modulation by NETO2. Nature, 599(7884), 325-329. https://doi.org/10.1038/s41586-021-03936-y.

3. Yang, W.^#, Wang, Y.^#, Guo, J.^#, He, L., Zhou, Y., Zheng, H., Liu, Z., Zhu, P.*, & Zhang, X. C.* (2020). Cryo-electron microscopy structure of CLHM1 ion channel from Caenorhabditis elegans. Protein science: a publication of the Protein Society, 29(8), 1803-1815. https://doi.org/10.1002/pro.3904.

4. Zhou, Y., Cao, C., He, L., Wang, X., & Zhang, X. C.* (2019). Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870. eLife, 8, e48822. https://doi.org/10.7554/eLife.48822.

5. Wang, Y.^#, Gao, H.^#, He, L.^#, Zhu, W., Yan, L., Chen, Q., & He, C.* (2019). The PHOSPHATE1 genes participate in salt and Pi signaling pathways and play adaptive roles during soybean evolution. BMC plant biology, 19(1), 353. https://doi.org/10.1186/s12870-019-1959-8.

6. Zhu, Y., He, L., Liu, Y., Zhao, Y., & Zhang, X. C.* (2019). smFRET Probing Reveals Substrate-Dependent Conformational Dynamics of E. coli Multidrug MdfA. Biophysical journal, 116(12), 2296-2303. https://doi.org/10.1016/j.bpj.2019.04.034.

7. Cao, C.^#, Tan, Q.^#, Xu, C., He, L., Yang, L., Zhou, Y., Zhou, Y., Qiao, A., Lu, M., Yi, C., Han, G. W., Wang, X., Li, X., Yang, H., Rao, Z., Jiang, H., Zhao, Y., Liu, J., Stevens, R. C., Zhao, Q., Zhang, X. C.*, Wu, B.* (2018). Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nature structural & molecular biology, 25(6), 488-495. https://doi.org/10.1038/s41594-018-0068-y.

8. Zhang, H., Qiao, A., Yang, L., Van Eps, N., Frederiksen, K. S., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Cao, C., He, L., Yang, H., Lau, J., Ernst, O. P., Hanson, M. A., Stevens, R. C., Wang, M. W., Reedtz-Runge, S., Jiang, H., Zhao, Q.*, Wu, B.* (2018). Structure of the glucagon receptor in complex with a glucagon analogue. Nature, 553(7686), 106-110. https://doi.org/10.1038/nature25153.

9. Zhao, M., Gu, Y., He, L., Chen, Q., & He, C.* (2015). Sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans. BMC plant biology, 15, 120. https://doi.org/10.1186/s12870-015-0519-0.

10. Wang, L., He, L., Li, J., Zhao, J., Li, Z., & He, C.* (2014). Regulatory change at Physalis Organ Size 1 correlates to natural variation in tomatillo reproductive organ size. Nature communications, 5, 4271. https://doi.org/10.1038/ncomms5271.

11. Zhao, M., He, L., Gu, Y., Wang, Y., Chen, Q., & He, C.* (2014). Genome-wide analyses of a plant-specific LIM-domain gene family implicate its evolutionary role in plant diversification. Genome biology and evolution, 6(4), 1000-1012. https://doi.org/10.1093/gbe/evu076.

12. He, L., Zhao, M., Wang, Y., Gai, J., & He, C.* (2013). Phylogeny, structural evolution and functional diversification of the plant PHOSPHATE1 gene family: a focus on Glycine max. BMC evolutionary biology, 13, 103. https://doi.org/10.1186/1471-2148-13-103.

(From Lingli He, March 22, 2022)