2007.09 – 2011.06  Shandong Normal University, B.S.

2011.09 – 2014.06  Shandong Normal University, M.S.

2014.09 – 2018.06  University of Chinese Academy of Sciences, Ph.D.

2018.09 – 2021.12  Institute of Biophysics, Chinese Academy of Sciences, Assistant Professor

2022.01 – 2022.10  Institute of Biophysics, Chinese Academy of Sciences, Associate Professor

1. The molecular and cellular logic underlying human interneuron diversity

Cortical neurons can be subdivided into two major classes: the excitatory glutamatergic pyramidal projection neurons, and the inhibitory GABAergic interneurons. GABAergic interneurons are considered to be an indispensable part of neural circuits and the main cellular elements that control hyperexcitability in the brain. And the interneuron diversity that varies widely in morphology, connectivity and patterns of activity is essential for fulfilling the intricate brain function.

2. The innovation and application of cerebral organoid

Cerebral organoids are neural tissues with similar 3D structure to human brains. Cerebral organoids can recapitulate the biological processes such as, neurogenesis, neural migration, cortical lamination as well as neural circuit establishment, in vivo. Besides, cerebral organoids can also be widely utilized to decipher the pathogeny of neuropsychological diseases.

1. Yingchao Shi; Mengdi wang; Da Mi; Tian Lu; Bosong Wang; Hao Dong; Suijuan Zhong; Youqiao chen; Le Sun; Xin Zhou; Qiang Ma; Zeyuan Liu; Wei Wang; Junjing Zhang; Qian Wu; Oscar Marin; Xiao qun Wang; Mouse and human share conserved transcriptional programs for interneuron development, Science, 2021, 374(6573): eabj6641

2. Yingchao Shi; Le Sun; Mengdi Wang; Jianwei Liu; Suijuan Zhong; Rui Li; Peng Li; Lijie Guo; Ai Fang; Ruiguo Chen; Woo-Ping Ge; Qian Wu; Xiaoqun Wang; Vascularized human cortical organoid s (vOrganoids) model cortical development in vivo, PLOS Biology, 2020, 18(5): e3000705

3. Yingchao Shi; Qian Wu; Xiaoqun Wang; Modeling brain development and diseases with human cerebral organoids, Current Opinion in Neurobiology, 2021, 66: 103-115

4. Yingchao Shi; Shihua Li; Qian Wu; Le Sun; Junjing Zhang; Na Pan; Qihui Wang; Yuhai Bi; Ji ng An; Xuancheng Lu; George Fu Gao; Xiaoqun Wang; Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring, Scientific Reports, 2018, 8(1): 3541

5. Zhihui Liu; Zijun Chen; Congping Shang; Fei Yan; Yingchao Shi; Jiajing Zhang; Baole Qu; H ailin Han; Yanying Wang; Dapeng Li; Thomas C. Sudhof; Peng Cao; IGF1-Dependent Synaptic Plastici ty of Mitral Cells in Olfactory Memory during Social Learning, Neuron, 2017, 95(1): 106-122

6. Congping Shang; Zhihui Liu; Zijun Chen; Yingchao Shi; Qian Wang; Su Liu; Dapeng Li; Peng Cao; A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice, Science, 2015, 348(6242): 1472-1477

7. Xin Zhou; Yufeng Lu; Fangqi Zhao; Ji Dong; Wenji Ma; Suijuan Zhong; Mengdi Wang; Bosong W ang; Yuqing Zhao; Yingchao Shi; Qiang Ma; Tian Lu; Jun Zhang; Xiaoqun Wang; Qian Wu; Deciphering the spatial-temporal transcriptional landscape of human hypothalamus development, Cell Stem Cell, 2022, 29(2): 328-343

8. Xiaoqun Wang; Qian Wu; Yingchao Shi; One culture method for establishing striatal organoids, 2020-1-20, China, 202010062009.0 (Patent)

(From Yingchao Shi, April 8, 2022)