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Zhenxing Zhang, Ph.D., Associate Professor

Member of the Youth Innovation Promotion Association of CAS
Chinese Academy of Sciences Key Laboratory of Infection and Immunity, IBP


Research Interests: Metabolic rewiring in the innate immune response


Email: zhangzx2008bz@ibp.ac.cn


Tel: 010-64888557


Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China


Chinese personal homepage


 

Biography

2008.09 - 2012.06  Bachelor, Binzhou University

2012.09 - 2015.06  Master, Wuhan University

2015.09 - 2019.06  Ph.D., Institute of Biophysics, Chinese Academy of Sciences

2019.07 - 2022.10  Postdoctoral fellow, Institute of Biophysics, Chinese Academy of Sciences

2022.10 -                Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

Awards
 
Membership in Academies & Societies
 
Research Interests

1. Uncover the new biological function of itaconate.

2. Identify the immunomodulatory metabolic enzymes and metabolites.

Grants

2021-2023  National Natural Science Foundation of China, Youth Fund Program (82003032)

Selected Publications

1. Zhang ZX#, Chen C#, Yang F, Zeng YX, Sun PK, Liu P, Li XJ*. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. Molecular Cell2022; 82(15): 2844-28574.

2. Sun PK#, Zhang ZX#, Wang B, Liu CY, Chen C, Liu P, Li XJ*. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nature Communications2022; 13(1): 65622.

3. Chen C#, Zhang ZX#, Liu CY, Wang B, Liu P, Fang S, Yang F, You YP, Li XJ*. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Nature Communications2022; 13(1): 61083.

4. Zhang ZX#, Li X#, Yang F#, Chen C#, Liu P, Ren Y, Sun PK, Wang ZX, You YP, Zeng YX, Li XJ*. DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis. Nature Communications2021; 12(1): 5872

5. Zhang C#, Gao Y#, Du C#, Markowitz GJ#, Fu J#, Zhang ZX, Liu C, Qin W, Wang H, Wang F*, Yang P*. Hepatitis B-induced IL-8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation. Cancer Research. 2021; 81(9): 2386-2398.

6. Tian Y#, Yang B#, Qiu W, Hao Y, Zhang ZX, Yang B, Li N, Cheng S, Lin Z, Rui YC, Cheung OKW, Yang W, Wu WKK, Cheung YS, Lai PBS, Luo J, Sung JJY, Chen R, Wang HY, Cheng ASL*, Yang P*. ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. Nature Communications. 2019; 10(1):3391.

7. Zhang ZX, Liu T, Yu M, Li KD, Li WH*. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. Journal of Experimental & Clinical Cancer Research. 2018, 37(1):7.

 

(From Zhenxing Zhang, February 1, 2023)

 

Contact Us

Tel: 010-64889872

E-Mail: webadmin@ibp.ac.cn

Address: No 15 Datun Road, Chaoyang District, Beijing

Postcode: 100101