2009.09 - 2013.07  B.Sc., Chengdu Technology University

2013.09 - 2019.12  Ph.D., Sichuan University

2020.01 - 2022.10  Postdoc, SINOVAC Biotech Ltd. / Institute of Biophysics, CAS

2022.10 -                Associate Professor, Institute of Biophysics, CAS

The major research focuses on the invasion mechanism, immune mechanism, and cross-species transmission mechanism of pathogens closely related to humans, and to reverse design of new vaccines and related antiviral drug development based on structure.

2023 - 2025  National Natural Science Foundation of China, Youth Fund Program.

2022 - 2025  Guangzhou National Laboratory Independent Project.

2022 - 2024  Young Elite Scientists Sponsorship Program by CAST

1. Qing Xiong^#; Lei Cao^#; M. Alejandra Tortorici ^#；Chengbao Ma^#; Chen Liu; Junyu Si; Peng Liu; Mengxue Gu; Chunli Wang; Lulu Shi; Fei Tong; Meiling Huang; Jing Li; Chufeng Zhao; Chao Shen; Yu Chen; Huabin Zhao; Ke Lan; Davide Corti; David Veesler; Xiangxi Wang; Huan Yan ; Close relatives of MERS-CoV in bats use ACE2 as their functional receptors, Nature, 2022, 612(1): 748-757. (共同一作)

2. Cui, Zhen^#; Liu, Pan^#; Wang, Nan^#; Wang, Lei^#; Fan, Kaiyue^#; Zhu, Qianhui^#; Wang, Kang^#; Chen, Ruihong; Feng, Rui; Jia, Zijing; Yang, Minnan; Xu, Ge; Zhu, Boling; Fu, Wangjun; Chu, Tianming; Feng, Leilei; Wang, Yide; Pei, Xinran; Yang, Peng; Xie, Xiaoliang Sunney; Cao, Lei*; Cao, Yunlong*; Wang, Xiangxi* ; Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron, Cell, 2022, 185(3): 860-871 (共同通讯)

3 Wang, kang^#; Jia, Zijing^#; Bao, Linlin^#; Wang, Lei^#; Cao, Lei^#; Chi, Hang^#; Hu, Yaling; Li, Qianqian; Zhou, Yunjiao; Jiang, Yinan; Zhu, Qianhui; Deng, Yongqiang; Liu, Pan; Wang, Nan; Wang, Lin; Liu, Min; Li, Yurong; Zhu, Boling; Fan, Kaiyue; Fu, Wangjun; Yang, Peng; Pei, Xinran; Cui, Zhen; Qin, Lili; Ge, Pingju; Wu, Jiajing; Liu, Shuo; Chen, Yiding; Huang, Weijin; Wang, Qiao; Qin, Cheng-Feng*; Wang, Youchun*; Qin, Chuan*; Wang, Xiangxi* ; Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants, Nature, 2022 (共同一作)

4. Sun, S., Gu, H., Cao, L., Chen, Q., Ye, Q., Yang, G., Li, R.-T., Fan, H., Deng, Y.Q., Song, X., Qi, Y., Li, M., Lan, J., Feng, R., Guo, Y., Zhu, N., Qin, S., Wang, L., Zhang, Y.-F., Zhou, C., Zhao, L., Chen, Y., Shen, M., Cui, Y., Yang, X., Wang, X., Tan, W., Wang, H., Wang, X. & Qin, C. F. Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2. Nat Commun, 12, 5654, doi:10.1038/s41467-021-25903-x (2021). (共同一作)

5. Zhang, Li^#; Cao, Lei^#; Gao, Xing-Su^#; Zheng, Bin-Yang^#; Deng, Yong-Qiang; Li, Jing-Xin; Feng,Rui; Bian, Qian; Guo, Xi-Ling; Wang, Nan; Qiu, Hong-Ying; Wang, Lei; Cui, Zhen; Ye, Qing; Chen, Geng; Lu, Kui-Kui; Chen, Yin; Chen, Yu-Tao; Pan, Hong-Xing; Yu, Jiaping; Yao, Wenrong; Zhu, Bao-Li; Chen, Jianping; Liu, Yong; Qin, Cheng-Feng*; Wang, Xiangxi*; Zhu, Feng-Cai* ; A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2, National Science Review, 2021,8(8): 0-nwab053 (共同一作)

6. Lv, Zhe^#; Deng, Yong-Qiang^#; Ye, Qing^#; Cao, Lei^#; Sun, Chun-Yun^#; Fan, Changfa^#; Huang, Weijin; Sun, Shihui; Sun, Yao; Zhu, Ling; Chen, Qi; Wang, Nan; Nie, Jianhui; Cui, Zhen; Zhu, Dandan; Shaw, Neil; Li, Xiao-Feng; Li, Qianqian; Xie, Liangzhi; Wang, Youchun; Rao, Zihe; Qin, Cheng-Feng; Wang, Xiangxi ; Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody, Science, 2020, 369(6510): 1505-1509(共同一作)

7. Cao, Lei^#; Liu, Pi^#; Yang, Pan^#; Gao, Qiang; Li, Hong; Sun, Yao; Zhu, Ling; Lin, Jianping; Su, Dan*; Rao, Zihe*; Wang, Xiangxi* ; Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors, Plos Biology, 2019, 17(4): 0-e3000229

(From Lei Cao, February 1, 2023)