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Lei Cao, Ph.D., Associate Professor

Member of the Youth Innovation Promotion Association of CAS
Member of Young Elite Scientists Sponsorship Program
Chinese Academy of Sciences Key Laboratory of Infection and Immunity, IBP


Research Interests: Viral structural biology


Email: catao1991@ibp.ac.cn


Tel: 010-64889939


Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China


Chinese personal homepage


 

Biography

2009.09 - 2013.07  B.Sc., Chengdu Technology University

2013.09 - 2019.12  Ph.D., Sichuan University

2020.01 - 2022.10  Postdoc, SINOVAC Biotech Ltd. / Institute of Biophysics, CAS

2022.10 -                Associate Professor, Institute of Biophysics, CAS

Awards
 
Membership in Academies & Societies
 
Research Interests

The major research focuses on the invasion mechanism, immune mechanism, and cross-species transmission mechanism of pathogens closely related to humans, and to reverse design of new vaccines and related antiviral drug development based on structure.

Grants

2023 - 2025  National Natural Science Foundation of China, Youth Fund Program.

2022 - 2025  Guangzhou National Laboratory Independent Project.

2022 - 2024  Young Elite Scientists Sponsorship Program by CAST

Selected Publications

1. Qing Xiong#; Lei Cao#; M. Alejandra Tortorici #;Chengbao Ma#; Chen Liu; Junyu Si; Peng Liu; Mengxue Gu; Chunli Wang; Lulu Shi; Fei Tong; Meiling Huang; Jing Li; Chufeng Zhao; Chao Shen; Yu Chen; Huabin Zhao; Ke Lan; Davide Corti; David Veesler; Xiangxi Wang; Huan Yan ; Close relatives of MERS-CoV in bats use ACE2 as their functional receptors, Nature, 2022, 612(1): 748-757. (共同一作)

2. Cui, Zhen#; Liu, Pan#; Wang, Nan#; Wang, Lei#; Fan, Kaiyue#; Zhu, Qianhui#; Wang, Kang#; Chen, Ruihong; Feng, Rui; Jia, Zijing; Yang, Minnan; Xu, Ge; Zhu, Boling; Fu, Wangjun; Chu, Tianming; Feng, Leilei; Wang, Yide; Pei, Xinran; Yang, Peng; Xie, Xiaoliang Sunney; Cao, Lei*; Cao, Yunlong*; Wang, Xiangxi* ; Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron, Cell, 2022, 185(3): 860-871 (共同通讯)

3 Wang, kang#; Jia, Zijing#; Bao, Linlin#; Wang, Lei#; Cao, Lei#; Chi, Hang#; Hu, Yaling; Li, Qianqian; Zhou, Yunjiao; Jiang, Yinan; Zhu, Qianhui; Deng, Yongqiang; Liu, Pan; Wang, Nan; Wang, Lin; Liu, Min; Li, Yurong; Zhu, Boling; Fan, Kaiyue; Fu, Wangjun; Yang, Peng; Pei, Xinran; Cui, Zhen; Qin, Lili; Ge, Pingju; Wu, Jiajing; Liu, Shuo; Chen, Yiding; Huang, Weijin; Wang, Qiao; Qin, Cheng-Feng*; Wang, Youchun*; Qin, Chuan*; Wang, Xiangxi* ; Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants, Nature, 2022 (共同一作)

4. Sun, S., Gu, H., Cao, L., Chen, Q., Ye, Q., Yang, G., Li, R.-T., Fan, H., Deng, Y.Q., Song, X., Qi, Y., Li, M., Lan, J., Feng, R., Guo, Y., Zhu, N., Qin, S., Wang, L., Zhang, Y.-F., Zhou, C., Zhao, L., Chen, Y., Shen, M., Cui, Y., Yang, X., Wang, X., Tan, W., Wang, H., Wang, X. & Qin, C. F. Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2. Nat Commun, 12, 5654, doi:10.1038/s41467-021-25903-x (2021). (共同一作)

5. Zhang, Li#; Cao, Lei#; Gao, Xing-Su#; Zheng, Bin-Yang#; Deng, Yong-Qiang; Li, Jing-Xin; Feng,Rui; Bian, Qian; Guo, Xi-Ling; Wang, Nan; Qiu, Hong-Ying; Wang, Lei; Cui, Zhen; Ye, Qing; Chen, Geng; Lu, Kui-Kui; Chen, Yin; Chen, Yu-Tao; Pan, Hong-Xing; Yu, Jiaping; Yao, Wenrong; Zhu, Bao-Li; Chen, Jianping; Liu, Yong; Qin, Cheng-Feng*; Wang, Xiangxi*; Zhu, Feng-Cai* ; A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2, National Science Review, 2021,8(8): 0-nwab053 (共同一作)

6. Lv, Zhe#; Deng, Yong-Qiang#; Ye, Qing#; Cao, Lei#; Sun, Chun-Yun#; Fan, Changfa#; Huang, Weijin; Sun, Shihui; Sun, Yao; Zhu, Ling; Chen, Qi; Wang, Nan; Nie, Jianhui; Cui, Zhen; Zhu, Dandan; Shaw, Neil; Li, Xiao-Feng; Li, Qianqian; Xie, Liangzhi; Wang, Youchun; Rao, Zihe; Qin, Cheng-Feng; Wang, Xiangxi ; Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody, Science, 2020, 369(6510): 1505-1509(共同一作)

7. Cao, Lei#; Liu, Pi#; Yang, Pan#; Gao, Qiang; Li, Hong; Sun, Yao; Zhu, Ling; Lin, Jianping; Su, Dan*; Rao, Zihe*; Wang, Xiangxi* ; Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors, Plos Biology, 2019, 17(4): 0-e3000229

 

(From Lei Cao, February 1, 2023)

 

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