Linchang Dai, Ph.D., Associate Professor
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Member of the Youth Innovation Promotion Association of CAS
National Laboratory of Biomacromolecules, IBP
Research Interests: Epigenetic regulation and DNA damage repair
Email: lcdai@ibp.ac.cn
Tel: 010-64889948
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
2012 - 2013 Ph.D in Biochemistry and Molecular Biology, University of Science and Technology of China
2013 - 2018 Ph.D, Institute of Biophysics (IBP), CAS
2019 - 2021 Postdoc, Institute of Biophysics, CAS
2022 - Associate Professor, Institute of Biophysics, CAS
- Awards
- Membership in Academies & Societies
- Research Interests
We combine multidisciplinary approaches including structural biology, biochemistry, cell biology and single-molecule biophysics to understand epigenetic regulation and DNA damage repair. Focus areas:
1. Nucleosomal histone post-transcriptional modifications (PTMs) in the DNA damage response.
2. Dynamic process of nucleosome editing (exchange of histone H2A.Z variant) catalyzed by the chromatin remodeling complex SWR1.
3. Structure of variant nucleosomes and their regulatory mechanisms for dynamic changes of chromatin structure.
- Grants
1. National Natural Science Foundation of China, General Program (32270580), 2023-2026
2. National Natural Science Foundation of China, Youth Scientist Program (32000421), 2021-2023
- Selected Publications
1. Dai L#, Dai Y#, Han J#, Huang Y#, Wang L, Huang J, Zhou Z, Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin. Molecular Cell, 2021, 2021, 81(13): 2765-2777.e6. (Recommended in F1000Prime)
2. Dai L#, Xiao X#, Pan L, Shi L, Xu N, Zhang Z, Feng X, Ma L, Li W, Zhou Z, Recognition of inherently unstable H2A-nucleosome by Swc2 are major determinants of unidirectional H2A.Z exchange. Cell Reports, 2021, 35(8): 109183.
3. Zhou M#, Dai L#, Li C, Shi L, Huang Y, Guo Z, Wu F, Xie X, Zhu P, Zhou Z, Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2. The EMBO Journal, 2020 e105907.
4. Dai L, Xu N, Zhou Z. NMR investigations on H2A-H2B heterodimer dynamics conferred by histone variant H2A.Z. Biochem Biophys Res Commun, 2019, 518:752-758.
5. Dai L#, Xie X#, Zhou Z. Crystal structure of the histone heterodimer containing histone variant H2A.Bbd. Biochem Biophys Res Commun, 2018, 503(3):1786-1791.
6. Huang Y, Sun L, Pierrakeas L, Dai L, Pan L, Luk E, Zhou Z, Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing, Proc. Natl. Acad. Sci, 2020, 117(7):3543-3550.
7. Mao Z, Pan L, Wang W, Sun J, Shan S, Dong Q, Liang X, Dai L, Ding X, Chen S, Zhang Z, Zhu B, Zhou Z. Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z. Cell Research, 2014, 24(4):389-99.
(From Linchang Dai, February 2, 2023)