2004.09 - 2008.07  B.S. in Biology, School of Life Sciences, Wuhan University

2008.09 - 2015.07  Ph.D. in Developmental Biology, University of Chinese Academy of Sciences (Institute for Health Science, Shanghai Institutes for Biological Sciences, CAS)

2015.07 - 2019.10  Assistant Professor, Beijing Institute of Genomics, CAS (National Center for Bioinformation)

2019.10 - 2023.03  Associate Professor, Beijing Institute of Genomics, CAS (National Center for Bioinformation)

2023.03 - 2023.06  Young Investigator, Beijing Institute of Genomics, CAS (National Center for Bioinformation)

2023.06 -                 Associate Professor, Institute of Biophysics, CAS

Focusing on Epigenetic Regulation in Embryo Development

(1) Elucidating the regulatory mechanisms of zygotic genome activation during human early embryo development (Cell 2018, Cell Discovery 2023a, Cell Discovery 2023b, Natl Sci Rev 2024a).

(2) Unveiling the epigenetic regulatory patterns of prefrontal cortex development in primates, providing potential theoretical insights into the cognitive differences between humans and non-human primates (Natl Sci Rev 2024b, Nat Commun 2022).

1. National Natural Science Foundation of China, General Program (32471502), 2025.01-2028.12.

2. National Key Research and Development Program (2022YFC2703302), 2022.12-2025.11.

3. Strategic Priority Research Program (Category B) of the Chinese Academy of Sciences (XDB38020500), 2020.01-2024.12.

4. Youth Innovation Promotion Association of CAS (2020000011), 2020.01-2023.12

5. National Natural Science Foundation of China, Youth Scientist Program (31601052), 2017.01-2019.12.

1. Chao Ning^#, Xi Wu^#, Xudong Zhao, Zongyang Lu, Xuelong Yao, Tao Zhou, Lizhi Yi, Yaoyu Sun, Shuaishuai Wu, Zhenbo Liu, Xingxu Huang*, Lei Gao*, Jiang Liu*. Epigenomic landscapes during prefrontal cortex development and aging in rhesus. Natl Sci Rev, 2024; 11(8):nwae213.

2. Shenli Yuan^#, Lei Gao^#*, Wenrong Tao^#, Jianhong Zhan^#, Gang Lu^#, Jingye Zhang, Chuanxin Zhang, Lizhi Yi, Zhenbo Liu, Zhenzhen Hou, Min Dai, Han Zhao, Zi-Jiang Chen*, Jiang Liu*, Keliang Wu*. Allelic reprogramming of chromatin states in human early embryos. Natl Sci Rev, 2024; 11(3):nwad328.

3. Keliang Wu^#, Dongdong Fan^#, Han Zhao, Zhenbo Liu, Zhenzhen Hou, Wenrong Tao, Guanling Yu, Shenli Yuan, Xiaoxiao Zhu, Mengyao Kang, Yong Tian*, Zi-Jiang Chen*, Jiang Liu*, Lei Gao*. Dynamics of histone acetylation during human early embryogenesis. Cell Discovery. 2023; 9(1):29.

4. Shenli Yuan^#, Jianhong Zhan^#, Jingye Zhang^#, Zhenbo Liu, Zhenzhen Hou, Chuanxin Zhang, Lizhi Yi, Lei Gao*, Han Zhao*, Zi-Jiang Chen*, Jiang Liu*, Keliang Wu*. Human zygotic genome activation is initiated from paternal genome. Cell Discovery. 2023; 9(1):13.

5. Xuelong Yao^#, Zongyang Lu^#, Zhanying Feng^#, Lei Gao^#, Xin Zhou, Min Li, Suijuan Zhong, Qian Wu, Zhenbo Liu, Haofeng Zhang, Zeyuan Liu, Lizhi Yi, Tao Zhou, Xudong Zhao, Jun Zhang, Yong Wang, Xingxu Huang*, Xiaoqun Wang*, Jiang Liu*. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human. Nat Commun. 2022; 13(1):3883.

6. Lei Gao^#, Keliang Wu^#, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Jianqiao Liu*, Zi-Jiang Chen*, Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and its Association with Evolution. Cell, 2018; 173(1):248-259.

7. Lei Gao, Dantong Li, Ke Ma, Wenjuan Zhang, Tao Xu, Cong Fu, Changbin Jing, Xiao-E Jia, Shuang Wu, Xin Sun, Mei Dong, Min Deng, Yi Chen, Wenger Zhu, Jinrong Peng, Fengyi Wan, Yi Zhou, Leonard I. Zon, Weijun Pan. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genetics, 2015; 11(7):e1005346.

8. Yuan Gao^#*, Lizhi Yi^#, Jianhong Zhan^#, Lijuan Wang^#, Xuelong Yao^#, Junhao Yan, Sijing Jian, Lei Gao, Mamadboqirova Farangez, Ming Gao, Yang Zou, Xuan Gao, Keliang Wu, Jiang Liu*, Zi-Jiang Chen*. A clinical study of preimplantation DNA methylation screening in assisted reproductive technology. Cell Res, 2023; 33(6):483-485.

9. Xinxin Wang^#, Xin Ma^#, Gaobo Wei^#, Weirui Ma, Zhen Zhang, Xuepeng Chen, Lei Gao, Zhenbo Liu, Yue Yuan, Lizhi Yi, Jun Wang, Toshinobu Tokumoto, Junjiu Huang, Dahua Chen*, Jian Zhang*, Jiang Liu*. The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish. Genomics Proteomics Bioinformatics, 2021 Feb;19(1):48-63.

10. Tao Huang^#, Shenli Yuan^#, Lei Gao, Mengjing Li, Xiaochen Yu, Jianhong Zhan, Yingying Yin, Chao Liu, Chuanxin Zhang, Gang Lu, Wei Li, Jiang Liu*, Zi-Jiang Chen*, Hongbin Liu*. The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair. Elife, 2020; 9:e53459.

11. Xuepeng Chen^#, Yuwen Ke^#, Keliang Wu^#, Han Zhao^#, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao, Zhenzhen Hou, Hui Liu, Jiang Liu*, Zi-Jiang Chen*. Key role for CTCF in establishing chromatin structure in human embryos. Nature, 2019; 576(7786):306-310.

12. Dantong Li^#, Wenzhi Xue^#, Mei Li^#, Mei Dong, Jianwei Wang, Xianda Wang, Xiyue Li, Kai Chen, Wenjuan Zhang, Shuang Wu, Yingqi Zhang, Lei Gao, Yujie Chen, Jianfeng Chen, Bo O Zhou, Yi Zhou, Xuebiao Yao, Lin Li, Dianqing Wu, Weijun Pan. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature, 2018; 564(7734):119-124.

13. Yuwen Ke^#, Yanan Xu^#, Xuepeng Chen^#, Songjie Feng, Zhenbo Liu, Yaoyu Sun, Xuelong Yao, Fangzhen Li, Wei Zhu, Lei Gao, Haojie Chen, Zhenhai Du, Wei Xie, Xiaocui Xu, Xingxu Huang*, Jiang Liu*. 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis. Cell, 2017; 170(2): 367-381.

(From Lei Gao, November 25, 2024)