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Tao Jiang, Ph.D, Prof.

Principal Investigator<br>
National Laboratory of Biomacromolecules, IBP

Research Interests: Structural and functional analysis of biomacromolecules and structure- based drug discovery

Email: tjiang@ibp.ac.cn

Tel: 010-64888510

Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China

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1987 - 1991  Bachelor of Chemistry, Xiamen University

1995 - 1998  PhD. of Biophysics, Institute of Biophysics, CAS

1999 - 2004  Associate professor, Institute of Biophysics, CAS

2004 -           Professor, Institute of Biophysics, CAS

Membership in Academies & Societies
Research Interests

In recent years, our group is concentrating on structural and functional analysis of biomacromolecules by use of structural biology approaches, with particular emphasis on the following aspects:

Our overall research goal is to determine the 3D-structure of these proteins, in conjugation with functional studies to decipher their molecular mechanisms and provide structure basis for the drug development for neurodegenerative diseases, cancer and metabolic disorders.

(1) Structual and function studies of neurotrophin, neurotrophin receptors and other cell surface receptors .

(2) Studies of DNA damage responses proteins and protein complexes .

(3) Structural analysis of enzymes related to the synthesis and metabolism of bioactive small moleclues.

Selected Publications

1. Huo YG*, Zhao HS, Dong QH, Jiang T* (2023) Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat. Microbiol. 8, 522–532 . https://doi.org/10.1038/s41564-022-01316-4

2. Li HL, Huo YG, He X, Yao LP, Zhang H, Cui YQ, Xiao HJ, Xie WX, Zhang DJ, Wang Y, Zhang S, Tu HX, Cheng YW, Guo YS, Cao XT, Zhu YF, Jiang T, Guo XJ*, Qin Y* & Sha JH*. (2022). A male germ-cell-specific ribosome controls male fertility. Nature. https://doi.org/10.1038/s41586-022-05508-0.

3. Tong Y, Ma X, Hu T, Chen K, Cui G, Su P, Xu H, Gao W*, Jiang T* and Huang L*. (2022) Structural and mechanisticinsights intothe precise product synthesis by a bifunctional miltiradiene synthase. Plant Biotechnol J. https://doi.org/10.1111/pbi.13933.

4. Huo Y. G., Li T., Wang N., Dong Q. H., Wang X. X., Jiang T.* (2018) Cryo-EM structure of Type III-A CRISPR effector complex. Cell Res. 10.1038/s41422-018-0115-6.

5. Xu M., Yang X., Yang X. A., Zhou L., Liu T.Z., Fan Z.*, Jiang T.*. (2016) Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system. Protein Cell, 7(6):403-16.

6. Wang T. Y., Sun H. L., Cheng F., Zhang X. E, Bi L. J. *, Jiang T.* (2013) Recognition and processing of double-stranded DNA by ExoX, a distributive 3’–5’exonuclease. Nucleic Acids Res, 41 (15): 7556-7565.

7. Tong Q., Wang F., Zhou H. Z., Sun H. L., Song H., Shu Y. Y., Gong Y., Zhang W. T., Cai T. X., Yang F. Q., Tang J., and Jiang T.* (2012) Structural and functional insights into lipid-bound nerve growth factors. FASEB J 26, 3811-3821

8. Gong Y., Zhu D., Ding J., Dou C. N., Ren X., Gu L., Jiang T.*, and Wang D. C.* (2011) Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Nat Struct Mol Biol 18, 1297-1299

9. Tang L., Bai L., Wang W. H., and Jiang T.* (2010) Crystal structure of the carnitine transporter and insights into the antiport mechanism. Nat Struct Mol Biol 17, 492-496

10. Xu M., Bai L., Gong Y., Xie W., Hang H.*, and Jiang T.* (2009) Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex. J Biol Chem 284, 20457-20461

11. Gong Y., Cao P., Yu H. J., and Jiang T.* (2008) Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature 454, 789-793

12. Tang L., Li M. H., Cao P., Wang F., Chang W. R., Bach S., Reinhardt J., Ferandin Y., Galons H., Wan Y., Gray N., Meijer L., Jiang T*., and Liang D. C.*(2005) Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem 280, 31220-31229

13. Li M. H., Kwok F., Chang W. R., Lau C. K., Zhang J. P., Lo S. C., Jiang T.*, and Liang D. C.* (2002) Crystal structure of brain pyridoxal kinase, a novel member of the ribokinase superfamily. J Biol Chem 277, 46385-46390


(From Tao Jiang, March 20, 2023)


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Tel: 010-64889872

E-Mail: webadmin@ibp.ac.cn

Address: No 15 Datun Road, Chaoyang District, Beijing

Postcode: 100101