Long Li, Ph.D, Prof.
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State Key Laboratory of Brain & Cognitive Sciences, IBP
Research Interests: The neural circuitry basis and therapeutic approaches for depression; the origins and neural circuitry basis of social reward; the impact of postnatal stress on susceptibility to stress in adulthood and its molecular and circuitry mechanisms; changes in hormone and neuropeptide receptors resulting from prolonged social and environmental stress and their functions.
Email: longli@ibp.ac.cn
Tel:
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
2006 - 2010 BSc, Qingdao University
2010 - 2013 MSc, Chinese Academy of Forestry
2013 - 2017 PhD, Institute of Biophysics, Chinese Academy of Sciences
2018 - 2022 Postdoc, Icahn School of Medicine at Mount Sinai
2022 - 2023 Instructor, Icahn School of Medicine at Mount Sinai
2023 - Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences
- Awards
- Membership in Academies & Societies
- Research Interests
- Grants
- Selected Publications
1. Li L, Durand R, Aubry A, Burnett C, Parise L, Cathomas F, Chan K, Yuan C, Morel C, Shimo Y, Lin H, Wang J, Russo S. Social trauma engages lateral septum circuitry to occlude social reward. Nature. 613, 696-703 (2023) https://doi.org/10.1038/s41586-022-05484-5
Research Highlight: Whalley, K. Avoiding social interactions. Nat Rev Neurosci (2022). https://doi.org/10.1038/s41583-022-00668-4
2. Poller, W.C., Downey, J., Mooslechner, A.A., Khan N, Li L, Chan C, McAlpine C, et al. Brain motor and fear circuits regulate leukocytes during acute stress. Nature. 607, 578-584 (2022). https://doi.org/10.1038/s41586-022-04890-z
3. Durand-de Cuttoli R, Martínez-Rivera FJ, Li L, Minier-Toribio A, Holt LM, Cathomas F, Yasmin F, Elhassa SO, Shaikh JF, Ahmed S, Russo SJ, Nestler EJ, Sweis BM. Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice. Science Adv. 2022 Oct 21;8(42):eadd5579. doi: 10.1126/sciadv.add5579. Epub 2022 Oct 19. PMID: 36260683; PMCID: PMC9581472.
4. Takahashi A, Durand-de Cuttoli R, Flanigan ME, Hasegawa E, Tsunematsu T, Aleyasin H, Cherasse Y, Miya K, Okada T, Keino-Masu K, Mitsui K, Li L, Patel V, Blitzer RD, Lazarus M, Tanaka KF, Yamanaka A, Sakurai T, Ogawa S, Russo SJ. Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nat Communication. 2022 Jul 21;13(1):4039. doi: 10.1038/s41467-022-31728-z. PubMed PMID: 35864121; PubMed Central PMCID: PMC9304121.
5. Morel C, Montgomery S, Li L, Durand R, Teichman E, Juarez B, Tzavaras N, Ku S, Flanigan M, Cai M, Walsh J, Russo S, Nestler E, Calipari E, Friedman A, Han M. Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors. Nature Communication 13, 1532 (2022). https://doi.org/10.1038/s41467-022-29155-1
6. Cathomas, F. Bevilacqua, L. Ramakrishnan, A. Kronman, H. Costi, S. Schneider, M. Chan, K. L. Li, L. Nestler, E. J. Shen, L. Charney, D. S. Russo, S. J. Murrough, J. W. Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression. Transl Psychiatry 12, 12 (2022).
7. Takahashi A, Aleyasin H, Stavarache MA, Li L, Cathomas F, Parise LF, Lin HY, Burnett CJ, Aubry A, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Sasaki T, Kaplitt MG, Ogawa S, McEwen BS, Russo SJ. Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression. Mol Psychiatry. 2021 Apr 30. doi: 10.1038/s41380-021-01110-4. PubMed PMID: 33931727.
8. Sun L*, Chen R*, Li L*, Yuan B*, Song K, Pan N, Cheng T, Chang S, Lin K, He X, Wu Q, Xu F, Qiu Z, Wang X. Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice. Science Bulletin. 2020/07; 65(14):1192-1202. (* Equal-contribution)
9. Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Durand-de Cuttoli R, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ. Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice. Nat Neurosci. 2020 May;23(5):638-650. doi: 10.1038/s41593-020-0617-7. Epub 2020 Apr 13. PubMed PMID: 32284606; PubMed Central PMCID: PMC7195257.
10. Zhong S, Zhang S, Fan X, Wu Q, Yan L, Dong J, Zhang H, Li L, Sun L, Pan N, Xu X, Tang F, Zhang J, Qiao J, Wang X. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature. 2018 Mar 22;555(7697):524-528. doi: 10.1038/nature25980. Epub 2018 Mar 14. PubMed PMID: 29539641.
11. Liu J, Liu W, Yang L, Wu Q, Zhang H, Fang A, Li L, Xu X, Sun L, Zhang J, Tang F, Wang X. The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. Cell Stem Cell. 2017 Nov 2;21(5):635-649.e8. doi: 10.1016/j.stem.2017.08.013. Epub 2017 Oct 12. PubMed PMID: 29033352.
(From Long Li, September 25, 2023)