2003 - 2007  School of Life Sciences, Lanzhou University, B.S.

2008 - 2014  Institute of Biophysics, Chinese Academy of Sciences, Ph.D

2015 - 2017  Institute of Biophysics, Chinese Academy of Sciences, Postdoc

2017 - 2021  Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

Viruses are closely related to human health. Viruses and hosts have been engaged in arms races for thousands of years, resulted in hosts evolving sophisticated antiviral defense systems and viruses evolving various molecular mechanisms that hijack or antagonize the host component. Viral genome replication and transcription is one of the most significant life activity, which performed via viral DNA replication complex or viral RNA polymerase. Elucidation of the interaction between the virus and its host and the mechanism of viral genome replication and transcription will be of great significant not only to virology and cell biology, but also to the structure-based development of the antiviral drugs. My research interests focus on the molecular mechanisms of viral genome replication and transcription machinery, as well as the important protein complexes involved in virus-host interactions using the integrated approaches of structural biology, biochemistry, biophysics and cell biology.

1. Jun Ma^#, Shuangyue Zhang^#, Xinzheng Zhang. Structure of Machupo virus polymerase in complex with matrix protein Z. Nature Communications, 2021, 12(1):6163.

2. Bingting Ma^#, Cuiqing Huang^#, Jun Ma^#, Ye Xiang*, Xinzheng Zhang*. Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3. Nature, 2021, 598(7882):677-681.

3. Lilan You^#, Jun Ma^#, Jiuyu Wang^#, Daria Artamonova, Min Wang, Liang Liu, Hua Xiang, Konstantin Severinov, Xinzheng Zhang*, Yanli Wang*. Structure studies of the CRISPR-Csm complex reveal mechanism of co-transcriptional interference. Cell, 2019, 176(1-2):239-253.

4. Xiaodong Su^#, Jun Ma^#, Xiaowei Pan^#, Xuelin Zhao, Wenrui Chang, Zhenfeng Liu, Xinzheng Zhang*, Mei Li*. Antenna arrangement and energy transfer pathways of a green algal photosystem I-LHCI supercomplex. Nature Plants, 2019, 5(3):273-281.

5. Jun Ma, Yujia Zhai, Ming Chen, Kai Zhang, Quan Chen, Xiaoyun Pang*, Fei Sun*. New interfaces on MiD51 for Drp1 recruitment and regulation. PLoS One, 2019, 14(1):e0211459.

6. Xiaowei Pan^#, Jun Ma^#, Xiaodong Su^#, Peng Cao, Wenrui Chang, Zhenfeng Liu, Xinzheng Zhang*, Mei Li*. Structure of the maize photosystem I supercomplex with light harvesting complexes I and II. Science, 2018, 360(6393):1109-1113.

7. Xiaodong Su^#, Jun Ma^#, Xuepeng Wei^#, Peng Cao^#, Dongjie Zhu, Wenrui Chang, Zhenfeng Liu*, Xinzheng Zhang*, Mei Li*. Structure and assembly mechanism of plant C₂S₂M₂-type PSII-LHCII supercomplex. Science, 2017, 357(6353):815-820.

8. Liang Liu^#, Xueyan Li^#, Jun Ma^#, Zongqiang Li^#, Lilan You, Jiuyu Wang, Min Wang, Xinzheng Zhang*, Yanli Wang*. The molecular architecture for RNA-guided RNA cleavage by Cas13a. Cell, 2017, 170(4):714-726.

9. Yuan Yuan^#, Duanfang Cao^#, Yanfang Zhang^#, Jun Ma^#, Jianxun Qi, Qihui Wang, Guangwen Lu, Ying Wu, Jinghua Yan, Yi Shi*, Xinzheng Zhang*, George F Gao*. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains. Nature Communications, 2017, 8:15092.

10. Jiuyu Wang^#, Jun Ma^#, Zhi Cheng, Xu Meng, Lilan You, Min Wang, Xinzheng Zhang*, Yanli Wang*. A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses. Cell Research, 2016, 26(10):1165-1168.

(From Jun Ma, November 2, 2021)