Zhenxing Zhang, Ph.D., Associate Professor
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Member of the Youth Innovation Promotion Association of CAS
Chinese Academy of Sciences Key Laboratory of Infection and Immunity, IBP
Research Interests: Metabolic rewiring in the innate immune response
Email: zhangzx2008bz@ibp.ac.cn
Tel: 010-64888557
Address: 15 Datun Road, Chaoyang District, Beijing, 100101, China
Chinese personal homepage
- Biography
2008.09 - 2012.06 Bachelor, Binzhou University
2012.09 - 2015.06 Master, Wuhan University
2015.09 - 2019.06 Ph.D., Institute of Biophysics, Chinese Academy of Sciences
2019.07 - 2022.10 Postdoctoral fellow, Institute of Biophysics, Chinese Academy of Sciences
2022.10 - Associate Professor, Institute of Biophysics, Chinese Academy of Sciences
- Awards
- Membership in Academies & Societies
- Research Interests
1. Uncover the new biological function of itaconate.
2. Identify the immunomodulatory metabolic enzymes and metabolites.
- Grants
2021-2023 National Natural Science Foundation of China, Youth Fund Program (82003032)
- Selected Publications
1. Zhang ZX#, Chen C#, Yang F, Zeng YX, Sun PK, Liu P, Li XJ*. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. Molecular Cell. 2022; 82(15): 2844-28574.
2. Sun PK#, Zhang ZX#, Wang B, Liu CY, Chen C, Liu P, Li XJ*. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nature Communications. 2022; 13(1): 65622.
3. Chen C#, Zhang ZX#, Liu CY, Wang B, Liu P, Fang S, Yang F, You YP, Li XJ*. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Nature Communications. 2022; 13(1): 61083.
4. Zhang ZX#, Li X#, Yang F#, Chen C#, Liu P, Ren Y, Sun PK, Wang ZX, You YP, Zeng YX, Li XJ*. DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis. Nature Communications. 2021; 12(1): 5872
5. Zhang C#, Gao Y#, Du C#, Markowitz GJ#, Fu J#, Zhang ZX, Liu C, Qin W, Wang H, Wang F*, Yang P*. Hepatitis B-induced IL-8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation. Cancer Research. 2021; 81(9): 2386-2398.
6. Tian Y#, Yang B#, Qiu W, Hao Y, Zhang ZX, Yang B, Li N, Cheng S, Lin Z, Rui YC, Cheung OKW, Yang W, Wu WKK, Cheung YS, Lai PBS, Luo J, Sung JJY, Chen R, Wang HY, Cheng ASL*, Yang P*. ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. Nature Communications. 2019; 10(1):3391.
7. Zhang ZX, Liu T, Yu M, Li KD, Li WH*. The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells. Journal of Experimental & Clinical Cancer Research. 2018, 37(1):7.
(From Zhenxing Zhang, February 1, 2023)