2006.09 - 2010.06  Bachelor in Biological Sciences, Shanxi University

2010.09 - 2015.06  Ph.D. in University of Chinese Academy of Sciences

2015.07 - 2018.12  Assistant Professor, Institute of Biophysics, CAS

2019.1 -                  Associate Professor, Institute of Biophysics, CAS

As a key molecular motor in eukaryotic cells, kinesin drives the directed transport of cargoes. Some kinesins are highly processive and capable of long-distance transport whereas some are immotile and may serve as tethers for signaling complexes. We are interested in regulation of motor protein movement, how motor activity is balanced and coordinated, how specific cargoes are recognized by motor protein, and how dysfunction in motor activity leads to human diseases.

1. Wang, W.J.^#, Ren, J.Q.^#, Song, W.Y.^#, Zhang, Y., Feng, W.* (2022) The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for auto inhibition. Nature Communications, 13,4281

2. Ren, J.Q.^#, Li, D.^#, Liu, J.Y.^#, Liu, H., Yan, X.M., Zhu, X.L.*, Feng, W.* (2022) Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation. Cell Reports, 41,111589

3. Cong, D.Z.^#, Ren, J.Q.^#, Zhou Y.R., Wang, S., Liang J.J., Ding, M.*, Feng, W.* (2021) Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A. PLOS Genetics, 17，e1009940

4. Ren, J.Q.^#, Liang, R.B.^#, Wang, W.J.^#, Zhang, D.C., Yu, L., and Feng, W.* (2020). Multi-site-mediated entwining of the linear WIR-motif around WIPI p-propellers for autophagy. Nature Communications, 11, 2702

5. Liang, R.B.^#, Ren, J.Q.^#, Zhang, Y., and Feng, W.* (2019). Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins. Journal of Molecular Biology, 431, 1494-1505.

6. Xu, Y.^#, Ren, J.Q.^#, He, X.^#, Chen, H., Wei, T.*, and Feng, W.* (2019). YWHA/14-3-3 proteins recognize phosphorylated TFEB by a non-canonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 1017-1030.

7. Ren, J.Q.^#, Wang, S.^#, Chen, H., Wang, W.J., Huo, L., and Feng, W.* (2018). Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition. PNAS, 115, E11933-E11942.

8. Ren, J.Q.^#, Zhang, Y.^#, Wang, S.^#, Huo, L., Lou, J., and Feng, W. (2018) Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement. Journal of Molecular Biology, 430, 2030-2041

9. Ren, J. Q.^#, Huo, L.^#, Wang, W. J., Zhang, Y., Li, W., Lou, J. Z., Xu, T., and Feng, W. . (2016) Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A. The Journal of Biological Chemistry, 291, 3581-3594

10. Ren, J. Q., Feng, L., Bai, Y. J., Pei, H. H., Yuan, Z. Q., and Feng, W.* (2015) Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule. Biochemical Journal, 468, 133-144

(From Jinqi Ren, February 2, 2023)