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HHMI Scientist Joachim Frank gives lecture at IBP

Updated: 2011-04-22

Professor Joachim Frank 
In the morning of 19th April, 2011, Professor Joachim Frank, a Howard Hughes Medical Institute (HHMI) Investigator and a member of the US National Academy of Sciences, visited the Institute of Biophysics (IBP) at the invitation of Professor Yan Qin.

Professor Frank gave a presentation titled “a molecular brownian machine” at IBP library. In his report, Professor Frank first introduced the basic principle and virtues of cryo-electron microscopy and single-particle reconstruction. Molecules and complexes could be frozen quickly and kept their natural state by freezing. Computer makes use of hundreds of thousands of photos from electron microscopy for a three-dimensional reconstruction. Professor Frank systematically introduced the interaction and structure changes of ribosomes, tRNA and various molecules (EF - Tu and EF - G) in protein translation processes. He observed that in the process of the shift of mRNA and tRNA relative to ribosomes, the proteins belonged to the big and small subunit of ribosome moved relative to ribosome and explained the mechanism of each process. During the over one-hour lecture, Professor Frank demonstrated three-dimensional structures of many ribosomes and translation factors and described a number of protein synthesis transport process models. 

 Professor Yan Qin

The lecture hall was filled with interested audiences during the whole presentation. Once Professor Frank finished his talk, many researchers and graduate students had a heated discussion with Professor Frank about relative research topics. They also took a picture together with him afterwards.

Professor Joachim Frank is a renowned structure biologist. His laboratory develops methods of cryo-electron microscopy and three-dimensional reconstruction to study the mechanism of protein biosynthesis. He is also Professor of Biochemistry and Molecular Biophysics and of Biological Sciences at Columbia University. He is also Research Professor of Cell Biology at New York University School of Medicine and Distinguished Professor at the State University of New York at Albany.

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